
Niraparib (R-enantiomer)
CAS No. 1038915-58-0
Niraparib (R-enantiomer)( Niraparib R-enantiomer | MK 4827 (R-enantiomer) )
Catalog No. M26298 CAS No. 1038915-58-0
Niraparib R-enantiomer is an inhibitor of PARP1(IC50 of 2.4 nM).
Purity : >98% (HPLC)






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Biological Information
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Product NameNiraparib (R-enantiomer)
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NoteResearch use only, not for human use.
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Brief DescriptionNiraparib R-enantiomer is an inhibitor of PARP1(IC50 of 2.4 nM).
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DescriptionNiraparib R-enantiomer is an inhibitor of PARP1(IC50 of 2.4 nM).(In Vitro):Niraparib R-enantiomer has somewhat lower in vitro metabolic clearance than the Niraparib S-enantiomer in rat liver microsomes, but Niraparib S-enantiomer is more potent in cell based assays (PARylation EC50, Niraparib R-enantiomer=30 nM, Niraparib S-enantiomer=4.0 nM; BRCA1-HeLa CC50, Niraparib R-enantiomer=470, Niraparib S-enantiomer=34 nM). .
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In VitroNiraparib R-enantiomer (MK-4827 R-enantiomer) resolution of Niraparib R-enantiomer give compounds Niraparib R-enantiomer and Niraparib S-enantiomer, both showing excellent inhibition of PARP-1. Niraparib R-enantiomer has somewhat lower in vitro metabolic clearance than the Niraparib S-enantiomer in rat liver microsomes, but Niraparib S-enantiomer is more potent in cell based assays (PARylation EC50, Niraparib R-enantiomer=30 nM, Niraparib S-enantiomer=4.0 nM; BRCA1-HeLa CC50, Niraparib R-enantiomer=470, Niraparib S-enantiomer=34 nM). Given this improved potency and similar in vitro turnover in human liver microsomes (HLM Clint, Niraparib R-enantiomer=4, Niraparib S-enantiomer=3 μL/min/mgP), Niraparib S-enantiomer (Niraparib) is focused on.
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In Vivo——
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SynonymsNiraparib R-enantiomer | MK 4827 (R-enantiomer)
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PathwayCell Cycle/DNA Damage
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TargetPARP
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RecptorFarnesyl transferase (FTase)| Parasite
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Research Area——
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Indication——
Chemical Information
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CAS Number1038915-58-0
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Formula Weight320.396
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Molecular FormulaC19H20N4O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : ≥ 32 mg/mL (99.88 mM)
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SMILESNC(=O)c1cccc2cn(nc12)-c1ccc(cc1)[C@H]1CCCNC1
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Costa SM, et al. Chemical constituents from Lippia sidoides and cytotoxic activity. J Nat Prod. 2001 Jun;64(6):792-5.
molnova catalog



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