Niraparib (R-enantiomer)

CAS No. 1038915-58-0

Niraparib (R-enantiomer)( Niraparib R-enantiomer | MK 4827 (R-enantiomer) )

Catalog No. M26298 CAS No. 1038915-58-0

Niraparib R-enantiomer is an inhibitor of PARP1(IC50 of 2.4 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 97 In Stock
5MG 160 In Stock
10MG 281 In Stock
25MG 485 In Stock
50MG 700 In Stock
100MG 981 In Stock
200MG Get Quote In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    Niraparib (R-enantiomer)
  • Note
    Research use only, not for human use.
  • Brief Description
    Niraparib R-enantiomer is an inhibitor of PARP1(IC50 of 2.4 nM).
  • Description
    Niraparib R-enantiomer is an inhibitor of PARP1(IC50 of 2.4 nM).(In Vitro):Niraparib R-enantiomer has somewhat lower in vitro metabolic clearance than the Niraparib S-enantiomer in rat liver microsomes, but Niraparib S-enantiomer is more potent in cell based assays (PARylation EC50, Niraparib R-enantiomer=30 nM, Niraparib S-enantiomer=4.0 nM; BRCA1-HeLa CC50, Niraparib R-enantiomer=470, Niraparib S-enantiomer=34 nM). .
  • In Vitro
    Niraparib R-enantiomer (MK-4827 R-enantiomer) resolution of Niraparib R-enantiomer give compounds Niraparib R-enantiomer and Niraparib S-enantiomer, both showing excellent inhibition of PARP-1. Niraparib R-enantiomer has somewhat lower in vitro metabolic clearance than the Niraparib S-enantiomer in rat liver microsomes, but Niraparib S-enantiomer is more potent in cell based assays (PARylation EC50, Niraparib R-enantiomer=30 nM, Niraparib S-enantiomer=4.0 nM; BRCA1-HeLa CC50, Niraparib R-enantiomer=470, Niraparib S-enantiomer=34 nM). Given this improved potency and similar in vitro turnover in human liver microsomes (HLM Clint, Niraparib R-enantiomer=4, Niraparib S-enantiomer=3 μL/min/mgP), Niraparib S-enantiomer (Niraparib) is focused on.
  • In Vivo
    ——
  • Synonyms
    Niraparib R-enantiomer | MK 4827 (R-enantiomer)
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    PARP
  • Recptor
    Farnesyl transferase (FTase)| Parasite
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1038915-58-0
  • Formula Weight
    320.396
  • Molecular Formula
    C19H20N4O
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : ≥ 32 mg/mL (99.88 mM)
  • SMILES
    NC(=O)c1cccc2cn(nc12)-c1ccc(cc1)[C@H]1CCCNC1
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Costa SM, et al. Chemical constituents from Lippia sidoides and cytotoxic activity. J Nat Prod. 2001 Jun;64(6):792-5.
molnova catalog
related products
  • BSI-201

    BSI-201 (Iniparib;NSC 746045;IND-71677;SAR240550) is a potent, small molecule PARP1 inhibitor with strong anti-neoplastic effect.

  • BYK204165

    BYK204165 is a potent PARP inhibitor?(PARP1; IC50 = 44.67 nM for human recombinant PARP1 in an enzyme assay).

  • Veliparib dihydrochl...

    Veliparib (ABT-888) is a potent, BBB penetrant, and orally active PARP inhibitor with IC50 of 5.2 and 2.9 nM for PARP-1 and PARP-2, respectively.